As a transplanted Floridian who lives in Western Carolina, I would suggest that if you are coming up on I-75, that you come up to I-575 and take that north. When 575 ends, continue on the same road until you get to Blairsville, GA. At the first traffic light in Blairsville, turn left - you are on the Murphy Highway, also known as 129. You can then follow 129 through Murphy NC, Andrews, NC, and then Robbinsville, NC.
That is simplest and quickest route to the "Tail."
Do not come up I-95 to I-26, use I-75 through Atlanta. Come directly through the center of Atlanta on 75 (Do not use I-285, it is so much slower) directly to I-575.