Danimal, I assume you are in the Jax area. I was just down there visiting family and it was still quicker down to I10 and east to I-95. Don't be afraid of downtown Atlanta, traffic usually moves pretty well.
If you have more than one person in the car, you can use the HOV lane and that nearly always moves quickly. Obviously, you don't want hit any city including Jax or Orlando at rush hour.
However you decide to come up, have a safe trip.