The poll asks which "do you have", so I answered that way. The question asks which "is better", which would be pretty hard to quantify. Personally, being able to drive to an Upsolute rep vs. mailing parts of my car across the country and waiting for them to return before I can drive my car again (the PowerChip process), and the price ($400 vs. $695), made the difference for me.

I saw an improvement of ~2-3MPG after getting Upsolute.

It doesn't matter when you do the chip in the process, unless you find an actual chip programmer that will specifically tune an ECU for your setup. Neither Upsolute nor PowerChip do that (nor anyone else I've found)... you get the same progamming regardless of any other mods you may have.