I'm sure wheel damage has occured during a blow-out, but that can happen on any car, even if it doesn't have low profile tires. It's just the price you pay for driving a sportscar. I hope you never buy a motorcycle.
Some people have purchased a donut spare to carry in case of an emergency. The fact that the tire sizes are staggered really doesn't matter, because we don't have a LSD.

Winstonscifi, you're right, no monitors in the base. No problem with using tire sealant. Until the guy changing your tire comes across it. Then he'll probably call you a few choice names.