I'm a new owner myself, and can offer these thoughts. Granted, I have an SRT6 with the AMG built engine, but I think this applies to all of the Crossfires.
IMHO, the Mercedes drivetrain is mechanically rock solid. However, like many cars, Crossfires have some "glitches" that will probably need to be addressed....
- Intercooler pump failures (SRT6 only, replace with Johnson pump)
- Sticky Ignition Switch (all models, free fix instructions on forum)
- Faulty solder connections on relay circuit board (free fix instructions on forum)
- Leaky plug adapter on automatic transmissions (inexpensive to fix)
- Water leaks around fixed spoiler mount (SRT6 only)
I'm sure there are a few I may have missed, but these are the ones I've worked on personally. I am pretty mechanically inclined, but I have to say that the Crossfire is an easy vehicle to work on yourself. I was apprehensive about doing my own work before I bought mine, but most of the routine maintenance is very straightforward. The oil change was one of the easiest I've ever done. I have now replaced all of the fluids, and none of them were difficult to do.
Now, if you have all of your service work done at a dealership, be prepared to spend some money.
I hope this helps. I'm sure other more experienced members will chime in as well.