Well I'm only guessing you found this....
OBD-II Trouble Code: P0300 Random/Multiple Cylinder Misfire Detected

How long since the plugs were done?
Remove your valve covers (have spare new valve cover gaskets if old ones are >20,000 miles or you dont know)
Get your hands in there (PITA), pull all your leads check they are hard to get off and hard to get on. Lead remover tool is good here for leverage.
Allow 2hrs and have some band aids handy.
OUCH!
OUCH!
You could go for a plug replacement while you're in there (again if life >50k miles or unknown), but if you're a tinkerer, you'll have those valve covers off again soon and plan to do it then.
https://www.crossfireforum.org/forum...tml#post261737

While everythings out - check the resistance of your coil packs. I cant recall the "good ohms number" - do a search.
http://www.ehow.com/how_4912368_chec...age-meter.html

Check your camshaft postion sensor as well if you're getting a P0341 or P3045, although you should get a CEL with that I think - and you're not.

If you want to go to another degree - be time prepared for giving your covers a good clean.