No, the Skreemulator works with all kind of RKE or Keyless Go Systems who is able to switch to ground for open/close also a push button will work. You can also disable the immobilizer function by a dip switch on the Skreemulator so that it always send a code to the ECU if it asks without a additional switch/RKE or so.
I haven't mention my keyless go system because the installation of it is not so easy, to do that you need a lot of experience in wiring electrical systems and read wiring diagrams. But for them they are interested, it's a EasyGuard PKE ec002-v-ns.