While that would presumptively seem to be the case, it is, in fact, not so in an OE setup.

The intercooler itself is a naturally occurring airlock. Merely by its location between the cylinder banks and the hoses feeding to/from it, air pockets will remain in the system unless it’s properly purged of its residual air. Neglecting to properly evacuate the fluid circuit will invariably result in higher IATs. Don't ask how I know.

OE intercooler fluid path, with yellow representing the air vent:

ICFliudCircuit.gif

AMG’s specified procedure is to activate the intercooler pump via STAR Diagnostics while gently “pinching off” the (red) return hose just above the ‘T’ junction. Direct the vent hose to a suitable container in order to contain the discharge until only fluid (sans air) is observed. Most simply energized the pump with 12 volts DC from an external source to get it spinning.

Shown on an E55:

airbleedweb.jpg
photo credit BrianS