I used to make that run during the holiday season, its around a thousand miles. That would be a good three day trip if we wanted to see some of the sights. To do it right it would take a week, with stops at the Colorado National Monument in Grand Junction, a night in Ourey for the mineral springs, a night in Durango and visit Mesa Verde the next day, a night in Alamosa and see the Great Sand Dunes National Monument on the way home. Lots of other places to stop along the way, winery's, brewery's, orchards etc.